symbiont-mediated suppression of host PKR/eIFalpha signaling

Term ID

GO:0039580

Synonyms

• suppression by virus of host EIF2AK2 activity
• suppression by virus of host PKR activity
• suppression by virus of host PKR signaling

Definition

A process in which a symbiont inhibits or disrupts host PKR (Protein Kinase regulated by RNA) signaling. PKR phosphorylates host targets such as the translation initiation factor eIF2alpha that inhibits protein synthesis as an antimicrobial response. Inhibition of host PKR signaling maintains the host ability to translate mRNA. The host is defined as the larger of the organisms involved in a symbiotic interaction. 15207627

References

• VZ:554

Ontology

GO: Biological Process    QuickGO    AmiGO