TCR signalosome

Term ID

GO:0036398

Synonyms

• LAT signalosome
• linker for activation of T cells signalosome

Definition

A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO