miRNA-mediated post-transcriptional gene silencing

Term ID

GO:0035195

Synonyms

• gene silencing by microRNA
• gene silencing by miRNA
• microRNA-mediated gene silencing
• miRNA-mediated gene silencing

Definition

A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. (6)

References

Ontology

GO: Biological Process    QuickGO    AmiGO