eukaryotic 48S preinitiation complex

Term ID

GO:0033290

Synonyms

• eukaryotic 48S initiation complex
• eukaryotic 48S pre-initiation complex

Definition

The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC. (4)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO