nuclear receptor coactivator activity

Term ID

GO:0030374

Synonyms

• ligand-activated RNA polymerase II transcription factor binding transcription factor activity
• ligand-dependent nuclear receptor transcription co-activator activity
• ligand-dependent nuclear receptor transcription coactivator activity
• nuclear receptor transcription coactivator activity
• transcription factor activity, ligand-activated RNA polymerase II transcription factor binding

Definition

A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

References

Ontology

GO: Molecular Function    QuickGO    AmiGO