oxidized purine nucleobase lesion DNA N-glycosylase activity

Term ID

GO:0008534

Synonyms

• 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity
• 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
• 8-oxoguanine DNA glycosylase activity
• bifunctional DNA glycosylase activity
• deoxyribonucleate glycosidase activity
• DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
• DNA glycosylase/AP-lyase activity
• DNA glycosylase/beta-lyase activity
• DNA-formamidopyrimidine glycosylase activity
• Fapy-DNA glycosylase activity
• formamidopyrimidine-DNA glycosylase activity
• Fpg protein
• oxidized purine base lesion DNA N-glycosylase activity
• purine-specific oxidized base lesion DNA N-glycosylase activity

Definition

Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. 11554296

References

• EC:3.2.2.23
• MetaCyc:3.2.2.23-RXN
• Reactome:R-HSA-110229
• Reactome:R-HSA-110243
• Reactome:R-HSA-110244

Ontology

GO: Molecular Function    QuickGO    AmiGO