glutamate decarboxylation to succinate

Term ID

GO:0006540

Synonyms

• 4-aminobutyrate shunt
• degradation of glutamate to succinate through GABA
• GABA shunt
• gamma-aminobutyrate shunt
• glutamate degradation via 4-aminobutyrate
• glutamate degradation via GABA

Definition

The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. 12740438

References

• MetaCyc:GLUDEG-I-PWY

Ontology

GO: Biological Process    QuickGO    AmiGO