MAP kinase activity

Term ID

GO:0004707

Synonyms

• ATP:protein phosphotransferase (MAPKK-activated) activity
• ERK
• ERK1
• ERK2
• extracellular signal-regulated kinase activity
• MAP kinase 1 activity
• MAP kinase 2 activity
• MAPK
• MBP kinase I activity
• MBP kinase II activity
• mitogen activated kinase activity
• mitogen-activated protein kinase activity
• myelin basic protein kinase activity
• SAP kinase activity
• SAPK
• stress-activated kinase activity
• stress-activated protein kinase activity

Definition

Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 0198547684

References

• EC:2.7.11.24
• KEGG_REACTION:R00162
• MetaCyc:2.7.11.24-RXN
• Reactome:R-HSA-111898
• Reactome:R-HSA-198733
• Reactome:R-HSA-445079
• Reactome:R-HSA-451366
• Reactome:R-HSA-5654560
• Reactome:R-HSA-5654562
• Reactome:R-HSA-5654565
• Reactome:R-HSA-5654566
• Reactome:R-HSA-73722
• Reactome:R-HSA-9626832

Ontology

GO: Molecular Function    QuickGO    AmiGO