Search Ontology:

GO: Molecular Function

glutamate-cysteine ligase activity

Term ID

GO:0004357

Synonyms

gamma-glutamyl-L-cysteine synthetase activity
gamma-glutamylcysteine synthetase activity
gamma-glutamylcysteinyl synthetase activity
L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity

Definition

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. 6.3.2.2

References

EC:6.3.2.2
KEGG_REACTION:R00894
MetaCyc:GLUTCYSLIG-RXN
RHEA:13285
Reactome:R-HSA-174367
Reactome:R-HSA-5602892

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: acid-amino acid ligase activity

acid-amino acid ligase activity Show first 5 Terms
negatively regulated by: negative regulation of glutamate-cysteine ligase activity

negative regulation of glutamate-cysteine ligase activity Show first 5 Terms
positively regulated by: positive regulation of glutamate-cysteine ligase activity

positive regulation of glutamate-cysteine ligase activity Show first 5 Terms
regulated by: regulation of glutamate-cysteine ligase activity

regulation of glutamate-cysteine ligase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations