aconitate hydratase activity

Term ID

GO:0003994

Synonyms

• aconitase activity
• cis-aconitase activity
• citrate hydro-lyase activity
• citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
• citrate(isocitrate) hydro-lyase activity

Definition

Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. 4.2.1.3

References

• EC:4.2.1.3
• MetaCyc:RXN-14047
• RHEA:10336
• Reactome:R-HSA-450975
• Reactome:R-HSA-5690911
• Reactome:R-HSA-70971

Ontology

GO: Molecular Function    QuickGO    AmiGO