3-methylcrotonyl-CoA carboxylase complex, mitochondrial

Term ID

GO:0002169

Synonyms

• mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme
• mitochondrial MCCC complex
• mitochondrial methylcrotonoyl-CoA carboxylase complex

Definition

A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO