oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Term ID

GO:0000703

Synonyms

• bifunctional DNA glycosylase
• DNA glycosylase/AP-lyase
• DNA glycosylase/beta-lyase
• endodeoxyribonuclease III
• endonuclease III
• endonuclease VIII activity
• oxidized pyrimidine base lesion DNA N-glycosylase activity
• pyrimidine-specific oxidized base lesion DNA N-glycosylase activity

Definition

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. 11554296

References

• Reactome:R-HSA-110224
• Reactome:R-HSA-110226
• Reactome:R-HSA-110227

Ontology

GO: Molecular Function    QuickGO    AmiGO