BN2 diffuse large B-cell lymphoma

Term ID

DOID:0081064

Synonyms

• BN2 DLBCL

Definition

A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding. (2)

References

• NCI:C148395

Ontology

Human Disease   ( DOID:0081064 )