natural killer cell

Term ID

CL:0000623

Synonyms

large granular lymphocyte
NK cell
null cell

Definition

A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. (2)

References

BTO:0000914
BTO:0004716
CALOHA:TS-0664
FMA:63147
FMA:83601
VHOG:0001697

Ontology

Cell Ontology

Relationships

develops from: pro-NK cell

pro-NK cell Show first 5 Terms
is a type of: group 1 innate lymphoid cell

group 1 innate lymphoid cell Show first 5 Terms
has subtype: CD94-negative, Ly49CI-negative natural killer cell hepatic pit cell immature natural killer cell mature natural killer cell pre-natural killer cell

CD94-negative, Ly49CI-negative natural killer cell hepatic pit cell immature natural killer cell mature natural killer cell pre-natural killer cell Show first 5 Terms
capable_of: natural killer cell mediated immunity regulation of immune response

natural killer cell mediated immunity regulation of immune response Show first 5 Terms
inverse disjoint_from: T cell

T cell Show first 5 Terms
lacks_plasma_membrane_part: CD3 epsilon CD14 molecule CD19 molecule membrane-spanning 4-domains subfamily A member 1

CD3 epsilon CD14 molecule CD19 molecule membrane-spanning 4-domains subfamily A member 1 Show first 5 Terms