baricitinib

Term ID

CHEBI:95341

Synonyms

1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
2-(3-(4-(3H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
baricitinib
baricitinibum
INCB 028050
INCB-028050
INCB028050
LY 3009104
LY-3009104
LY3009104
Olumiant
{1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile

Definition

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis.

References

cas:1187594-09-7
chemspider:26373084
drugbank:DB11817
hmdb:HMDB0248873
kegg.drug:D10308
lincs.smallmolecule:LSM-6709
pdb-ccd:3JW
pmc:PMC8606629
pubmed:26853940
pubmed:27910962
pubmed:30036348
pubmed:30871014
pubmed:30907116
pubmed:32856090
pubmed:33451175
pubmed:33456084
pubmed:33502499
pubmed:33870531
pubmed:33961266
pubmed:34110416
pubmed:34195587
pubmed:34237007
pubmed:34247230
pubmed:34250455
pubmed:34321249
pubmed:34358107
pubmed:34379541
pubmed:34393789
pubmed:34424311
pubmed:34468689
pubmed:34501467
pubmed:34553429
pubmed:34647989
pubmed:34747511
pubmed:34785883
wikipedia.en:Baricitinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from baricitinib

Phenotype where environments contain baricitinib

Phenotype modified by environments containing baricitinib

Phenotype affecting baricitinib

Human Disease Model