LY404039

Term ID

CHEBI:94640

Synonyms

(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid
(1R,4S,5S,6S)-4-amino-2,2-dioxo-2lambda(6)-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
LY 404039
LY-404,039
LY-404039
LY404039
pomaglumetad

Definition

An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: bridged compound dicarboxylic acid non-proteinogenic amino acid derivative organic heterobicyclic compound sulfone

bridged compound dicarboxylic acid non-proteinogenic amino acid derivative organic heterobicyclic compound sulfone Show first 5 Terms
has_role: antipsychotic agent anxiolytic drug dopamine agonist metabotropic glutamate receptor agonist

antipsychotic agent anxiolytic drug dopamine agonist metabotropic glutamate receptor agonist Show first 5 Terms

Phenotype

Phenotype resulting from LY404039

Phenotype where environments contain LY404039

Phenotype modified by environments containing LY404039

Human Disease / Model Data

Citations