simvastatin

Term ID

CHEBI:9150

Synonyms

• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
• MK-733
• simvastatin
• Simvastatina
• Simvastatine
• Simvastatinum
• Zocor

Definition

A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.

References

• Beilstein:4768037
• CAS:79902-63-9
• DrugBank:DB00641
• Drug_Central:2445
• HMDB:HMDB0005007
• KEGG:D00434
• LINCS:LSM-2492
• PMID:11336576
• PMID:12827636
• PMID:14561068
• PMID:14691614
• PMID:14973129
• PMID:16144183
• PMID:17640385
• PMID:18199328
• PMID:18688862
• PMID:18936176
• PMID:22737247
• Patent:EP33538
• Patent:US4444784
• Wikipedia:Simvastatin

Ontology

ChEBI  ( EBI )

Resources

CTD