osimertinib

Term ID

CHEBI:90943

Synonyms

AZD 9291
AZD-9291
AZD9291
mereletinib
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
osimertinib
osimertinibum

Definition

A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: acrylamides aminopyrimidine biaryl indoles monomethoxybenzene ... Show All 9 Terms

acrylamides aminopyrimidine biaryl indoles monomethoxybenzene secondary amino compound secondary carboxamide substituted aniline tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent epidermal growth factor receptor antagonist

antineoplastic agent epidermal growth factor receptor antagonist Show first 5 Terms
inverse is_conjugate_acid_of: osimertinib(1+)

osimertinib(1+) Show first 5 Terms
is_conjugate_base_of: osimertinib(1+)

osimertinib(1+) Show first 5 Terms

Phenotype

Phenotype resulting from osimertinib

Phenotype where environments contain osimertinib

Phenotype modified by environments containing osimertinib

Human Disease / Model Data

Citations