irinotecan hydrochloride hydrate

Term ID

CHEBI:90881

Synonyms

(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride--water (1/3)
1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride--water (1/3)
Camptosar
CPT 11
CPT-11
Irinotecan hydrochloride
irinotecan hydrochloride trihydrate
irinotecan monohydrochloride trihydrate
ONIVYDE
U-101,440E

Definition

A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrate

hydrate Show first 5 Terms
has_part: irinotecan hydrochloride (anhydrous)

irinotecan hydrochloride (anhydrous) Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug

antineoplastic agent apoptosis inducer EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from irinotecan hydrochloride hydrate

Phenotype where environments contain irinotecan hydrochloride hydrate

Phenotype modified by environments containing irinotecan hydrochloride hydrate

Human Disease / Model Data

Citations