sonidegib

Term ID

CHEBI:90863

Synonyms

• Erismodegib
• LDE 225
• LDE-225
• LDE225
• N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
• NVP-LDE 225
• NVP-LDE225
• rel-N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
• sonidegib

Definition

A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.

References

• cas:956697-53-3
• drugcentral:5008
• kegg.drug:D10119
• lincs.smallmolecule:LSM-4938
• pubmed:23482671
• pubmed:23935925
• pubmed:24523439
• pubmed:24817600
• pubmed:25093491
• pubmed:25216523
• pubmed:25473003
• pubmed:25981810
• pubmed:26106586
• pubmed:26483188
• pubmed:26516158
• pubmed:26546616
• reaxys:19431762
• wikipedia.en:Sonidegib

Ontology

ChEBI  ( EBI )