RU 58668

Term ID

CHEBI:90223

Synonyms

• (11beta,17beta)-11-[4-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl]estra-1,3,5(10)-triene-3,17-diol
• 11beta-[4-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl]-17beta-estradiol
• 11beta-[4-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl]estra-1,3,5(10)-triene-3,17beta-diol
• RU 58 668
• RU 58,668
• RU-58668
• RU58668

Definition

A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 58668 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM).

References

• CAS:151555-47-4
• PMID:12880293
• PMID:14757510
• PMID:16753295
• PMID:7625719
• PMID:8142294
• PMID:8879676
• PMID:9010350
• PMID:9355049
• Reaxys:7454158

Ontology

ChEBI  ( EBI )

Resources

CTD