Search Ontology:
ChEBI
SN-38
- Term ID
- CHEBI:8988
- Synonyms
-
- (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hydroxy-7-ethylcamptothecin
- 7-Ethyl-10-hydroxy-20(S)-camptothecin
- 7-Ethyl-10-hydroxycamptothecin
- NK 012
- NK-012
- SN 38
- SN 38 lactone
- SN-38
- Definition
- A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
- References
-
- CAS:86639-52-3
- HMDB:HMDB0060510
- KEGG:C11173
- PDBeChem:RS4
- PMID:23921491
- PMID:24194565
- PMID:24477982
- PMID:24494988
- PMID:24842785
- PMID:24990485
- PMID:25233635
- PMID:25910639
- PMID:25917289
- PMID:26080460
- PMID:26106073
- PMID:26330269
- PMID:26337772
- PMID:26381056
- PMID:26505475
- PMID:26518357
- PMID:26526067
- PMID:26529243
- PMID:26541586
- PMID:26656185
- PMID:26695118
- PMID:26728136
- PMID:31321449
- PMID:31707444
- PMID:31956782
- PMID:32032928
- PMID:32104495
- PMID:32385283
- PMID:32387182
- PMID:33125824
- PMID:33138058
- PMID:33475937
- PMID:33615176
- PMID:33774525
- PMID:33851564
- Reaxys:4829984
- Wikipedia:SN-38
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
- inverse has_functional_parent
-
Show first 5 Terms
Phenotype
Phenotype resulting from SN-38
Phenotype where environments contain SN-38
Phenotype modified by environments containing SN-38
Human Disease / Model Data
Citations