5'-ATGGACCAAAGAGTTTCAGGGA-3'

Term ID

CHEBI:85516

Synonyms

• 5'-ApTpGpGpApCpCpApApApGpApGpTpTpTpCpApGpGpGpA-3'
• 5'-d[ATGGACCAAAGAGTTTCAGGGA]-3'
• d(A-T-G-G-A-C-C-A-A-A-G-A-G-T-T-T-C-A-G-G-G-A)
• d(ATGGACCAAAGAGTTTCAGGGA)
• HPS

Definition

A single-stranded DNA oligonucleotide comprised of eight deoxyadenosine, four thymidine, three deoxycytidine and seven deoxyguanosine residues connected by 3'->5' phosphodiester linkages in the sequence ATGGACCAAAGAGTTTCAGGGA. It is a mimic of HuR mRNA nucleotides 671-692 and acts as an antagonist that deregulates human antigen R (HuR) expression and inhibits AKT(SER473) phosphorylation in prostate and other cancers.

References

Ontology

ChEBI  ( EBI )