Search Ontology:
ChEBI

2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate

Term ID
CHEBI:85310
Synonyms
  • 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone
  • 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate
  • BiP inducer X
  • BIX
  • immunoglobulin heavy-chain binding protein inducer X
Definition
A member of the class of thiocyanates that is 3,4-dihydroxyacetophenone in which one of the methyl hydrogens has been replaced by the sulfur of a cyanosulfanediyl (-SC#N) group. It has been found to induce the expression of the endoplasmic reticulum chaperone protein GRP78 (78 kDa glucose-regulated protein, BiP, a highly conserved member of the 70 kDa heat shock protein family) leading to an attenuation of the unfolded protein response. It protects neuronal cells and retinal cells from endoplasmic reticulum (ER)-stress induced cell death.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
Phenotype
Phenotype resulting from 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate
Phenotype where environments contain 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate
Phenotype modified by environments containing 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate
Human Disease / Model Data
Citations
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