vorapaxar

Term ID

CHEBI:82702

Synonyms

ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
vorapaxar

Definition

A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethynyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: carbamate ester lactone naphthofuran organofluorine compound pyridines

carbamate ester lactone naphthofuran organofluorine compound pyridines Show first 5 Terms
has_role: cardiovascular drug platelet aggregation inhibitor protease-activated receptor-1 antagonist

cardiovascular drug platelet aggregation inhibitor protease-activated receptor-1 antagonist Show first 5 Terms
inverse is_conjugate_acid_of: vorapaxar(1+)

vorapaxar(1+) Show first 5 Terms
is_conjugate_base_of: vorapaxar(1+)

vorapaxar(1+) Show first 5 Terms

Phenotype

Phenotype resulting from vorapaxar

Phenotype where environments contain vorapaxar

Phenotype modified by environments containing vorapaxar

Human Disease / Model Data

Citations