ponatinib

Term ID

CHEBI:78543

Synonyms

3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
AP 24534
AP-24534
AP24534
ponatinib
ponatinibum

Definition

A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes acetylenic compound benzamides imidazopyridazine N-methylpiperazine

(trifluoromethyl)benzenes acetylenic compound benzamides imidazopyridazine N-methylpiperazine Show first 5 Terms
has_role: antineoplastic agent tyrosine kinase inhibitor

antineoplastic agent tyrosine kinase inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: ponatinib(1+)

ponatinib(1+) Show first 5 Terms
is_conjugate_base_of: ponatinib(1+)

ponatinib(1+) Show first 5 Terms

Phenotype

Phenotype resulting from ponatinib

Phenotype where environments contain ponatinib

Phenotype modified by environments containing ponatinib

Human Disease / Model Data

Citations