Src Inhibitor-1

Term ID

CHEBI:78332

Synonyms

(4'-oxyphenyl-phenylamino)-6,7-dimethoxyquinazoline
4-(4'-phenoxyanilino)-6,7-dimethoxyquinazoline
6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
SKI-1
Src kinase inhibitor I
Src-l1

Definition

A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.

References

LINCS:LSM-3112
PMID:17850214
Reaxys:8790191

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether polyether quinazolines secondary amino compound

aromatic ether polyether quinazolines secondary amino compound Show first 5 Terms
has_role: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor

EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from Src Inhibitor-1

Phenotype where environments contain Src Inhibitor-1

Phenotype modified by environments containing Src Inhibitor-1

Human Disease / Model Data

Citations