temafloxacin

Term ID

CHEBI:77788

Synonyms

• (+-)-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• (+-)-temafloxacin
• A 62254
• rac-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• rac-temafloxacin
• T 1258
• temafloxacin
• temafloxacine
• temafloxacino
• temafloxacinum

Definition

A racemate comprising equimolar amounts of (R)- and (S)-temafloxacin. Both enantiomers both exhibit similar pharmacological profiles. Temafloxacin was briefly used (either as the free base or as the hydrochloride salt) as an antibacterial drug but was withdrawn worldwide in 1992 following reports of serious side effects, including severe hypoglycaemia, haemolytic anaemia, liver and kidney dysfunction, anaphylaxis, and death.

References

• CAS:108319-06-8
• DrugBank:DB01405
• PMID:1318680
• PMID:1319872
• PMID:1662889
• PMID:1662893
• PMID:1662895
• PMID:1666497
• PMID:1846917
• Patent:EP131839
• Patent:US4730000
• Reaxys:4301726
• Wikipedia:Temafloxacin

Ontology

ChEBI  ( EBI )

Resources

CTD