teniposide

Term ID

CHEBI:75988

Synonyms

• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside
• HSDB 6546
• NSC 122819
• NSC-122819
• teniposide
• teniposido
• teniposidum
• VM-26
• VM26
• Vumon

Definition

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.

References

• CAS:29767-20-2
• DrugBank:DB00444
• Drug_Central:2590
• HMDB:HMDB0014587
• KEGG:C11153
• KEGG:D02698
• MetaCyc:CPD-16755
• PDBeChem:9TP
• PMID:1063066
• PMID:11516526
• PMID:1329226
• PMID:1411642
• PMID:1411643
• PMID:21430063
• PMID:21821840
• PMID:22644709
• PMID:22771706
• PMID:22846410
• PMID:23266449
• PMID:23466610
• PMID:23679827
• PMID:23838380
• PMID:24969912
• PMID:25151861
• PMID:25448575
• PMID:25899285
• PMID:26253377
• PMID:27596115
• PMID:30409428
• PMID:32015321
• PMID:32194707
• Reaxys:1417328
• Wikipedia:Teniposide

Ontology

ChEBI  ( EBI )

Resources

CTD