deglymidodrine

Term ID

CHEBI:73248

Synonyms

(+-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol
(+/-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol
1-(2',5'-dimethoxyphenyl)aminoethanol
alpha-(aminomethyl)-2,5-dimethoxybenzenemethanol
de-glymidodrine
desglymidodrine
rac-2-amino-1-(2,5-dimethoxyphenyl)ethanol
ST-1059

Definition

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.

References

CAS:3600-87-1
PMID:15537169
PMID:16242885
PMID:23051063
Reaxys:3262168

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether primary amino compound secondary alcohol

aromatic ether primary amino compound secondary alcohol Show first 5 Terms
has_role: alpha-adrenergic agonist sympathomimetic agent vasoconstrictor agent

alpha-adrenergic agonist sympathomimetic agent vasoconstrictor agent Show first 5 Terms
inverse has_functional_parent: midodrine

midodrine Show first 5 Terms

Phenotype

Phenotype resulting from deglymidodrine

Phenotype where environments contain deglymidodrine

Phenotype modified by environments containing deglymidodrine

Human Disease / Model Data

Citations