(-)-noscapine

Term ID

CHEBI:73237

Synonyms

(-)-alpha-narcotine
(-)-narcotine
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
alpha-Narcotine
noscapina
noscapine
noscapinum

Definition

A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.

References

CAS:128-62-1
Drug_Central:1973
HMDB:HMDB0033439
KEGG:C09592
KEGG:D01036
KNApSAcK:C00001891
LINCS:LSM-3997
MetaCyc:CPD-14834
PMID:22079300
PMID:22546556
PMID:22653730
PMID:22671862
PMID:22733149
PMID:22848370
PMID:22935070
PMID:23117045
Reaxys:99933
Wikipedia:Noscapine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether benzylisoquinoline alkaloid cyclic acetal isobenzofuranone organic heterobicyclic compound ... Show All 7 Terms

aromatic ether benzylisoquinoline alkaloid cyclic acetal isobenzofuranone organic heterobicyclic compound organic heterotricyclic compound tertiary amino compound Show first 5 Terms
has_functional_parent: (-)-noscapine hemiacetal

(-)-noscapine hemiacetal Show first 5 Terms
has_role: antineoplastic agent antitussive apoptosis inducer plant metabolite

antineoplastic agent antitussive apoptosis inducer plant metabolite Show first 5 Terms

Phenotype

Phenotype resulting from (-)-noscapine

Phenotype where environments contain (-)-noscapine

Phenotype modified by environments containing (-)-noscapine

Human Disease / Model Data

Citations