lomitapide

Term ID

CHEBI:72297

Synonyms

• AEGR 733
• AEGR 773
• AEGR-773
• AEGR733
• AEGR773
• BMS 201038
• BMS201038
• Lojuxta
• lomitapida
• lomitapide
• lomitapidum
• N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide

Definition

A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.

References

• CAS:182431-12-5
• DrugBank:DB08827
• Drug_Central:4721
• KEGG:D09637
• PMID:17215532
• PMID:20127562
• PMID:21846156
• PMID:22963620
• PMID:23122767
• PMID:23122768
• PMID:23147576
• PMID:24366202
• PMID:25257075
• PMID:25702706
• PMID:26120010
• PMID:26686567
• PMID:27055957
• PMID:27232459
• PMID:27785928
• PMID:28154305
• PMID:28239069
• PMID:28255870
• PMID:28432645
• PMID:28598687
• PMID:28716835
• Patent:US2003162788
• Patent:US2008161279
• Patent:US2010273829
• Patent:US2011288064
• Patent:US2011288110
• Patent:US2012035204
• Patent:US2012071458
• Reaxys:13754976
• Wikipedia:Lomitapide

Ontology

ChEBI  ( EBI )