cobicistat

Term ID

CHEBI:72291

Synonyms

• 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
• cobicistat
• cobicistatum
• GS 9350
• GS-9350

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications..

References

• CAS:1004316-88-4
• Drug_Central:4299
• PMID:20043009
• PMID:20683270
• PMID:21348537
• PMID:22732469
• PMID:22766666
• PMID:22833060
• PMID:22850510
• PMID:22886031
• PMID:23136357
• PMID:23243633
• Patent:US2010256366
• Patent:WO2008010921
• Patent:WO2012151165
• Reaxys:13088386
• Wikipedia:Cobicistat

Ontology

ChEBI  ( EBI )