doxapram

Term ID

CHEBI:681848

Synonyms

• (+-)-doxapram
• 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
• 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
• doxapram

Definition

A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

References

• Beilstein:628691
• CAS:309-29-5
• DrugBank:DB00561
• Drug_Central:953
• KEGG:D07873
• LINCS:LSM-5058
• PMID:19663568
• PMID:20140700
• PMID:25819170
• PMID:26896538
• PMID:4122029
• PMID:4126096
• PMID:527638
• Patent:BE613734
• Patent:US3192206
• Reaxys:628691
• VSDB:1819
• Wikipedia:Doxapram

Ontology

ChEBI  ( EBI )

Resources

CTD