integrastatin A

Term ID

CHEBI:66079

Synonyms

4,7,8-trihydroxy-1-(hydroxymethyl)-3,9-dimethoxy-6,12-dimethyl-6H-6,12-epoxydibenzo[b,f]oxocin-11(12H)-one
rac-4,7,8-trihydroxy-1-(hydroxymethyl)-3,9-dimethoxy-6,12-dimethyl-6H-6,12-epoxydibenzo[b,f]oxocin-11(12H)-one

Definition

An organic heterotetracyclic compound that is 6H-6,12-epoxydibenzo[b,f]oxocin-11(12H)-one substituted by hydroxy groups at positions 4, 7 and 8, a hydroxymethyl group position 1, methyl groups at positions 6 and 12 and methoxy groups at positions 3 and 9. It is isolated as a racemate from Unidentified fungi (New mexico) and has been shown to exhibit inhibitory activity against HIV-1 integrase.

References

Reaxys:9166117

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether bridged compound cyclic ether cyclic ketone organic heterotetracyclic compound ... Show All 7 Terms

aromatic ether bridged compound cyclic ether cyclic ketone organic heterotetracyclic compound polyphenol primary alcohol Show first 5 Terms
has_role: HIV-1 integrase inhibitor metabolite

HIV-1 integrase inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from integrastatin A

Phenotype where environments contain integrastatin A

Phenotype modified by environments containing integrastatin A

Human Disease / Model Data

Citations