metergoline

Term ID

CHEBI:64216

Synonyms

• (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid benzyl ester
• (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl ester
• (+)-N-(Carboxy)-1-methyl-9,10-dihydrolysergamine benzyl ester
• 1,6-Dimethyl-8-beta-carbobenzyloxaminomethyl-10-alpha-ergoline
• 1-Methyl-8-beta-carbobenzyloxyaminomethyl-10-alpha-ergoline
• 1-Methyl-N-carbobenzyloxydihydro-D-lysergamin
• benzyl {[(8alpha)-1,6-dimethylergolin-8-yl]methyl}carbamate
• D-8-beta-((Carbobenzoxyamino)methyl)-1,6-dimethyl-10-alpha-ergoline
• D-8-beta-((Carboxyamino)methyl)-1,6-dimethylergoline benzyl ester
• Metergolin
• metergolina
• metergoline
• metergolinum

Definition

An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.

References

• CAS:17692-51-2
• Drug_Central:1723
• KEGG:D07218
• LINCS:LSM-3265
• PMID:18996971
• PMID:19484723
• PMID:19509219
• PMID:19538518
• PMID:19539656
• PMID:19632276
• PMID:19945477
• PMID:20377624
• PMID:20451398
• PMID:20845263
• PMID:21354537
• PMID:21475142
• PMID:21600959
• PMID:21880033
• PMID:22218419
• PMID:24134630
• Reaxys:5362415
• Wikipedia:Metergoline

Ontology

ChEBI  ( EBI )

Resources

CTD