clobenpropit

Term ID

CHEBI:64177

Synonyms

3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate
S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea

Definition

An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: imidazoles imidothiocarbamic ester organochlorine compound

imidazoles imidothiocarbamic ester organochlorine compound Show first 5 Terms
has_role: H3-receptor antagonist H4-receptor agonist

H3-receptor antagonist H4-receptor agonist Show first 5 Terms
inverse is_conjugate_acid_of: clobenpropit(2+)

clobenpropit(2+) Show first 5 Terms
is_conjugate_base_of: clobenpropit(2+)

clobenpropit(2+) Show first 5 Terms

Phenotype

Phenotype resulting from clobenpropit

Phenotype where environments contain clobenpropit

Phenotype modified by environments containing clobenpropit

Human Disease / Model Data

Citations