2-methyl-6-(phenylethynyl)pyridine

Term ID

CHEBI:64159

Synonyms

2-methyl-6-(phenylethynyl)pyridine
6-Methyl-2-(phenylethynyl)pyridine
MPEP

Definition

A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetylenic compound methylpyridines

acetylenic compound methylpyridines Show first 5 Terms
has_parent_hydride: acetylene

acetylene Show first 5 Terms
has_role: anxiolytic drug metabotropic glutamate receptor antagonist

anxiolytic drug metabotropic glutamate receptor antagonist Show first 5 Terms
inverse is_conjugate_acid_of: 2-methyl-6-(phenylethynyl)pyridinium(1+)

2-methyl-6-(phenylethynyl)pyridinium(1+) Show first 5 Terms
is_conjugate_base_of: 2-methyl-6-(phenylethynyl)pyridinium(1+)

2-methyl-6-(phenylethynyl)pyridinium(1+) Show first 5 Terms

Phenotype

Phenotype resulting from 2-methyl-6-(phenylethynyl)pyridine

Phenotype where environments contain 2-methyl-6-(phenylethynyl)pyridine

Phenotype modified by environments containing 2-methyl-6-(phenylethynyl)pyridine

Human Disease / Model Data

Citations