Search Ontology:
ChEBI

2-methyl-6-(phenylethynyl)pyridine hydrochloride

Term ID
CHEBI:64158
Synonyms
  • 2-methyl-6-(phenylethynyl)pyridine hydrochloride
  • 2-methyl-6-(phenylethynyl)pyridinium chloride
  • 6-methyl-2-(phenylethynyl)pyridine hydrochloride
  • 6-methyl-2-(phenylethynyl)pyridinium chloride
  • MPEP hydrochloride
Definition
A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
Phenotype
Phenotype resulting from 2-methyl-6-(phenylethynyl)pyridine hydrochloride
Phenotype where environments contain 2-methyl-6-(phenylethynyl)pyridine hydrochloride
Phenotype modified by environments containing 2-methyl-6-(phenylethynyl)pyridine hydrochloride
Human Disease / Model Data
Citations
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