GR 127935 hydrochloride

Term ID

CHEBI:64111

Synonyms

4-[2-methoxy-5-({[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}amino)phenyl]-1-methylpiperazin-1-ium chloride
GR127935 hydrochloride
N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride

Definition

A hydrochloride obtained by reaction of GR 127935 with one equivalent of hydrochloric acid. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.

References

Reaxys:8530522

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: GR 127935(1+)

GR 127935(1+) Show first 5 Terms
has_role: serotonergic antagonist

serotonergic antagonist Show first 5 Terms

Phenotype

Phenotype resulting from GR 127935 hydrochloride

Phenotype where environments contain GR 127935 hydrochloride

Phenotype modified by environments containing GR 127935 hydrochloride

Human Disease / Model Data

Citations