amorolfine

Term ID

CHEBI:599440

Synonyms

(+-)-cis-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
(2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
amorolfina
amorolfine
amorolfinum
meso-2,6-dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine
meso-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine

Definition

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.

References

Beilstein:8154195
CAS:78613-35-1
Drug_Central:188
KEGG:D01720
KEGG:D02923
PMID:17620378
Wikipedia:Amorolfine

Ontology

ChEBI ( EBI )

Relationships

is a type of: morpholine antifungal drug tertiary amino compound

morpholine antifungal drug tertiary amino compound Show first 5 Terms
has_role: EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor EC 1.14.13.132 (squalene monooxygenase) inhibitor EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor

EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor EC 1.14.13.132 (squalene monooxygenase) inhibitor EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor Show first 5 Terms
inverse is_conjugate_base_of: amorolfine(1+)

amorolfine(1+) Show first 5 Terms
is_conjugate_acid_of: amorolfine(1+)

amorolfine(1+) Show first 5 Terms

Phenotype

Phenotype resulting from amorolfine

Phenotype where environments contain amorolfine

Phenotype modified by environments containing amorolfine

Human Disease / Model Data

Citations