colistimethate

Term ID

CHEBI:59662

Synonyms

Definition

A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid. It is prepared from colistin by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic, it is used as its penta-sodium salt in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

References

DrugBank:DB01111
PMID:16931410

Ontology

ChEBI ( EBI )

Relationships

is a type of: amino sulfonic acid peptide antibiotic polymyxin

amino sulfonic acid peptide antibiotic polymyxin Show first 5 Terms
has_functional_parent: colistin

colistin Show first 5 Terms
has_part: colistimethate A colistimethate B

colistimethate A colistimethate B Show first 5 Terms
has_role: prodrug

prodrug Show first 5 Terms
inverse is_conjugate_base_of: colistimethate(5-)

colistimethate(5-) Show first 5 Terms
is_conjugate_acid_of: colistimethate(5-)

colistimethate(5-) Show first 5 Terms

Phenotype

Phenotype resulting from colistimethate

Phenotype where environments contain colistimethate

Phenotype modified by environments containing colistimethate

Human Disease / Model Data

Citations