pizotifen

Term ID

CHEBI:50212

Synonyms

4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
pizotifen
pizotifene
pizotifeno
pizotifenum
Pizotyline

Definition

A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.

References

Beilstein:753534
CAS:15574-96-6
Drug_Central:2220
KEGG:D05523
LINCS:LSM-3695
Patent:BE636717
Patent:US3272826
Reaxys:753534
Wikipedia:Pizotifen

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: benzocycloheptathiophene

benzocycloheptathiophene Show first 5 Terms
has_functional_parent: piperidine

piperidine Show first 5 Terms
has_role: histamine antagonist muscarinic antagonist serotonergic antagonist

histamine antagonist muscarinic antagonist serotonergic antagonist Show first 5 Terms
inverse is_conjugate_acid_of: pizotifen(1+)

pizotifen(1+) Show first 5 Terms
is_conjugate_base_of: pizotifen(1+)

pizotifen(1+) Show first 5 Terms

Phenotype

Phenotype resulting from pizotifen

Phenotype where environments contain pizotifen

Phenotype modified by environments containing pizotifen

Human Disease / Model Data

Citations