diazoxide

Term ID

CHEBI:4495

Synonyms

• 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Diazossido
• Diazoxide
• diazoxido
• diazoxidum
• Eudemine

Definition

A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

References

• Beilstein:523907
• CAS:364-98-7
• DrugBank:DB01119
• Drug_Central:854
• HMDB:HMDB0015251
• KEGG:C06949
• KEGG:D00294
• LINCS:LSM-3639
• PMID:11014217
• PMID:12039709
• PMID:15319354
• PMID:16740260
• PMID:16777075
• PMID:18191077
• PMID:20828743
• PMID:20950601
• PMID:21538163
• PMID:21693179
• PMID:22047130
• PMID:29438107
• Patent:DE723278
• Patent:US2986573
• Patent:US3345365
• Reaxys:523907
• Wikipedia:Diazoxide

Ontology

ChEBI  ( EBI )

Resources

CTD