desferrioxamine B

Term ID

CHEBI:4356

Synonyms

• Deferoxamin
• deferoxamina
• deferoxamine
• deferoxaminum
• Deferrioxamine
• deferrioxamine B
• Desferrioxamine
• desferrioxamine-B
• DFO
• DFOB
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-(5-{4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanamido}pentyl)-N-hydroxybutanediamide
• N(4)-{5-[acetyl(hydroxy)amino]pentyl}-N(1)-(5-{4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanamido}pentyl)-N(1)-hydroxybutanediamide

Definition

An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

References

• Beilstein:2514118
• CAS:70-51-9
• Chemspider:2867
• DrugBank:DB00746
• Drug_Central:792
• HMDB:HMDB0014884
• KEGG:C06940
• KEGG:D03670
• LINCS:LSM-6541
• LIPID_MAPS_instance:LMFA08020169
• PMID:11239825
• PMID:18536609
• PMID:28156129
• PMID:28285915
• PMID:28318697
• PMID:28455567
• PMID:29182270
• PMID:30701380
• PMID:31035197
• PMID:31229836
• PMID:31846315
• PMID:32039778
• PMID:32572744
• PMID:32734456
• PMID:32856363
• PMID:33784308
• Patent:BE609053
• Wikipedia:Deferoxamine

Ontology

ChEBI  ( EBI )

Resources

CTD