Search Ontology:
ChEBI

4-phenylbutyric acid

Term ID
CHEBI:41500
Synonyms
  • 4-PHENYL-BUTANOIC ACID
  • 4-Phenyl-n-butyric acid
  • 4-phenylbutanoic acid
  • Benzenebutyric acid
  • gamma-Phenyl-n-butyric acid
  • gamma-phenylbutyric acid
  • omega-Phenylbutanoic acid
  • omega-phenylbutyric acid
  • PBA
Definition
A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
inverse is_conjugate_base_of
is_conjugate_acid_of
Phenotype
Phenotype resulting from 4-phenylbutyric acid
Phenotype where environments contain 4-phenylbutyric acid
Phenotype modified by environments containing 4-phenylbutyric acid
Human Disease / Model Data
Citations
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