aldosterone

Term ID

CHEBI:27584

Synonyms

(+)-aldosterone
(11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al
11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al
11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
ALDOSTERONE

Definition

A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.

References

Beilstein:3224996
CAS:52-39-1
DrugBank:DB04630
Drug_Central:111
HMDB:HMDB0000037
KEGG:C01780
LINCS:LSM-42770
LIPID_MAPS_instance:LMST02030026
PDBeChem:AS4
PMID:10438974
Reaxys:3224996
Wikipedia:Aldosterone

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 3-oxo-Delta(4) steroid 11beta-hydroxy steroid 18-oxo steroid 20-oxo steroid 21-hydroxy steroid ... Show All 9 Terms

3-oxo-Delta(4) steroid 11beta-hydroxy steroid 18-oxo steroid 20-oxo steroid 21-hydroxy steroid C21-steroid hormone mineralocorticoid primary alpha-hydroxy ketone steroid aldehyde Show first 5 Terms
has_parent_hydride: pregnane

pregnane Show first 5 Terms
has_role: human metabolite mouse metabolite

human metabolite mouse metabolite Show first 5 Terms
inverse has_functional_parent: 5alpha-dihydroaldosterone 5beta-dihydroaldosterone aldosterone hemiacetal

5alpha-dihydroaldosterone 5beta-dihydroaldosterone aldosterone hemiacetal Show first 5 Terms

Phenotype

Phenotype resulting from aldosterone

Phenotype where environments contain aldosterone

Phenotype modified by environments containing aldosterone

Human Disease / Model Data

Citations