Search Ontology:
ChEBI
TAK-733
- Term ID
- CHEBI:231366
- Synonyms
-
- (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
- 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
- 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodo-phenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7-dione
- TAK 733
- TAK733
- Definition
- A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione substituted by (2R)-2,3-dihydroxypropyl, (2-fluoro-4-iodophenyl)amino, fluoro, and methyl groups at positions 3, 5, 6, and 8, respectively. It is a non-ATP competitive allosteric inhibitor of MEK1/2.
- References
-
- CAS:1035555-63-5
- DrugBank:DB12241
- PDBeChem:IZG
- PMID:21310613
- PMID:22515704
- PMID:25376610
- PMID:26014721
- PMID:26439693
- PMID:26918363
- PMID:27650277
- PMID:28258008
- PMID:29674718
- PMID:30396931
- PMID:30714951
- PMID:33327491
- PMID:34534577
- PMID:35269397
- PMID:38027011
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from TAK-733
Phenotype where environments contain TAK-733
Phenotype modified by environments containing TAK-733
Human Disease / Model Data
Citations