Search Ontology:
ChEBI
varlitinib
- Term ID
- CHEBI:231356
- Synonyms
-
- AR-00334543
- AR00334543
- ARRY 334543
- ARRY-334543
- ARRY-543
- ASLAN-001
- ASLAN001
- N(4)-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-N(6)-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
- varlitinib
- varlitinibum
- Definition
- A member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours.
- References
-
- CAS:845272-21-1
- DrugBank:DB05944
- KEGG:D09689
- PMCID:PMC6421168
- PMCID:PMC6421180
- PMCID:PMC6421189
- PMID:24939447
- PMID:30002279
- PMID:30658422
- PMID:31652942
- PMID:32606601
- PMID:34028091
- PMID:34156519
- PMID:34922298
- PMID:35195837
- PMID:36098367
- PMID:36341365
- PMID:36479120
- PMID:37470935
- PMID:38697849
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from varlitinib
Phenotype where environments contain varlitinib
Phenotype modified by environments containing varlitinib
Human Disease / Model Data
Citations