Search Ontology:
ChEBI
PLS-123
- Term ID
- CHEBI:230531
- Synonyms
-
- 2-methyl-N-[2-(3-{[N-(prop-2-enoyl)glycyl]amino}anilino)pyrimidin-5-yl]-5-[3-(trifluoromethyl)benzamido]benzamide
- N-(2-((3-(2-acrylamidoacetamido)phenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide
- PLS 123
- PLS123
- Definition
- A member of the class of pyrimidines that is pyrimidine substituted by (3-{[N-(prop-2-enoyl)glycyl]amino}phenyl)amino and {2-methyl-5-[3-(trifluoromethyl)benzamido]benzoyl}nitrilo groups at positions 2 and 5, respectively. It is a covalent BTK inhibitor with potential anti-proliferative activity. It exhibits more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical models of B-cell lineage malignancy, including tumor cell lines and mouse xenograft models.
- References
-
- CAS:1431727-04-6
- PMID:24915291
- PMID:25944695
- PMID:28905990
- PMID:33479682
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from PLS-123
Phenotype where environments contain PLS-123
Phenotype modified by environments containing PLS-123
Human Disease / Model Data
Citations